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Welcome to the Centre for Pathogen Evolution

The Centre for Pathogen Evolution is based within the Department of Zoology, at the University of Cambridge. The Pathogen Evolution Group is dedicated to research in antigenically variable pathogens and pathogen evolution, and to contribute to basic science and critical issues in public health. The Pathogen Evolution Group conducts highly translational scientific research focused on improving our understanding and ability to predict pathogen evolution in humans and other animals, provides support to the World Health Organization (WHO) influenza vaccine strain selection process, and develops and distributes free high-quality software.

WHO and Influenza

Influenza: The World Health Organisation's health topic page on influenza provides links to descriptions of activities, reports, publications, statistics, news, multimedia and events.

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This group and our research, is and has been possible, due to the generous support of the NIH Director's Pioneer Award, the NIH NIAID Centers for Excellence in Influenza Research, the Human Frontier Science Program, the European Union Framework 7 project Emperie, European Union Framework 7 project Antigone, IFPMA, HBLB, FLUAID, Framework 6 Virgil project, Framework 5 Novaflu project, University of Wisconsin System (funded by the Bill & Melinda Gates Foundation), University of Wisconsin-Madison, Wellcome Trust and Horizon2020.

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Please click here then click on the Sign Up link on that page if you would like to use alpha release of our web-based software for making and viewing antigenic maps. Note IE is not supported.

Key Publications

Derek J. Smith, Alan S. Lapedes, et al, (2004). Mapping the Antigenic and Genetic Evolution of Influenza Virus Science 305(5682):371-376.

Colin A. Russell, Terry C. Jones, et al, (2008). The Global Circulation of Seasonal Influenza A (H3N2) Viruses Science 320(5874):340-346.

Björn F. Koel, David F. Burke, et al, (2013). Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution Science 342(6161):976-979.

J. M. Fonville, S. H. Wilks, et al, (2014). Antibody landscapes after influenza virus infection or vaccination Science 346(6212):996-1000

Colin A. Russell, Judith M. Fonville, et al, (2012). The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host Science 336(6088):1541-1547