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PhD Student Applications

Evolution of Influenza Viruses - prediction of possible future antigenic variants

Our research focus is to design and develop analytical, computational, and mathematical methods to understand the fundamental processes that govern the evolution of influenza viruses. The aim is to translate this understanding into the prediction of possible future antigenic variants to guide phase II clinical trials of next generation influenza vaccines. Our research is highly interdisciplinary and involves substantial global collaboration with experimental virologists, immunologists and clinicians to quantify the selection pressures on influenza viruses to better understand their evolutionary dynamics, and to inform control strategies. 

 

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Software

Please click here then click on the Sign Up link on that page if you would like to use alpha release of our web-based software for making and viewing antigenic maps. Note IE is not supported.

Key Publications

Derek J. Smith, Alan S. Lapedes, et al, (2004). Mapping the Antigenic and Genetic Evolution of Influenza Virus Science 305(5682):371-376.

Colin A. Russell, Terry C. Jones, et al, (2008). The Global Circulation of Seasonal Influenza A (H3N2) Viruses Science 320(5874):340-346.

Björn F. Koel, David F. Burke, et al, (2013). Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution Science 342(6161):976-979.

J. M. Fonville, S. H. Wilks, et al, (2014). Antibody landscapes after influenza virus infection or vaccination Science 346(6212):996-1000

Colin A. Russell, Judith M. Fonville, et al, (2012). The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host Science 336(6088):1541-1547